Summary: I guess you've had enough of viruses and pandemics but imagine this:
The Wizarding World is often protrayed as quite backward; thus vaccinations were only introduced (as a concept) after Grindelwald's defeat, and many older people (especially lawmakers in the Wizengamot) are against vaccinations as a concept (perhaps due to prejudice against Muggles). Then, an epidemic or a pandemic of a disease breaks out that people could have been vaccinated against, but the vaccine lost its efficacy due to spread in the population and mutations.
How does Hogwarts react to this? Or look wider, if you wish.
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